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Crystal structure of Aristaless and Clawless homeodomains bound to DNA

X-ray diffraction
2.7Å resolution
PDB entry 3a01 coloured by chain, front view.
PDB entry 3a01 coloured by chain, side view.
PDB entry 3a01 coloured by chain, top view.
Source organism: Drosophila melanogaster
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Homeobox domain-containing protein and Homeobox protein aristaless and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 13027.62 Å2
Buried surface area: 6775.37 Å2
Dissociation area: 1,303.78 Å2
Dissociation energy (ΔGdiss): 8.4 kcal/mol
Dissociation entropy (TΔSdiss): 10.9 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-116053
Assembly 2
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Assembly Name: Homeobox domain-containing protein and Homeobox protein aristaless and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 12615.06 Å2
Buried surface area: 6188.55 Å2
Dissociation area: 1,160.86 Å2
Dissociation energy (ΔGdiss): 8.73 kcal/mol
Dissociation entropy (TΔSdiss): 10.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-116053

Macromolecules

Homeobox domain-containing protein
Chains: A, E
Length: 93 amino acids
Theoretical weight: 11.19 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9VD99 (Residues: 169-261; Coverage: 30%)
Gene names: C15, CG7937
Pfam: Homeodomain
InterPro:
CATH: Homeodomain-like
Homeobox domain-containing protein in PDB entry 3a01, assembly 1, front view.
Homeobox domain-containing protein in PDB entry 3a01, assembly 1, side view.
Homeobox domain-containing protein in PDB entry 3a01, assembly 1, top view.
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Homeobox protein aristaless
Chains: B, F
Length: 67 amino acids
Theoretical weight: 8.34 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06453 (Residues: 80-146; Coverage: 16%)
Gene names: CG3935, al
Pfam: Homeodomain
InterPro:
CATH: Homeodomain-like
Homeobox protein aristaless in PDB entry 3a01, assembly 1, front view.
Homeobox protein aristaless in PDB entry 3a01, assembly 1, side view.
Homeobox protein aristaless in PDB entry 3a01, assembly 1, top view.
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DNA chains C, G
Name: 5'-D(*GP*GP*CP*TP*TP*AP*AP*TP*TP*AP*AP*TP*TP*GP*CP*GP*G)-3'
Representative chains: C, G
Length: 17 nucleotides
Theoretical weight: 5.26 KDa
5'-D(*GP*GP*CP*TP*TP*AP*AP*TP*TP*AP*AP*TP*TP*GP*CP*GP*G)-3' in PDB entry 3a01, assembly 1, front view.
5'-D(*GP*GP*CP*TP*TP*AP*AP*TP*TP*AP*AP*TP*TP*GP*CP*GP*G)-3' in PDB entry 3a01, assembly 1, side view.
5'-D(*GP*GP*CP*TP*TP*AP*AP*TP*TP*AP*AP*TP*TP*GP*CP*GP*G)-3' in PDB entry 3a01, assembly 1, top view.
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DNA chains D, H
Name: 5'-D(*CP*CP*GP*CP*AP*AP*TP*TP*AP*AP*TP*TP*AP*AP*GP*CP*C)-3'
Representative chains: D, H
Length: 17 nucleotides
Theoretical weight: 5.16 KDa
5'-D(*CP*CP*GP*CP*AP*AP*TP*TP*AP*AP*TP*TP*AP*AP*GP*CP*C)-3' in PDB entry 3a01, assembly 1, front view.
5'-D(*CP*CP*GP*CP*AP*AP*TP*TP*AP*AP*TP*TP*AP*AP*GP*CP*C)-3' in PDB entry 3a01, assembly 1, side view.
5'-D(*CP*CP*GP*CP*AP*AP*TP*TP*AP*AP*TP*TP*AP*AP*GP*CP*C)-3' in PDB entry 3a01, assembly 1, top view.
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