› 3mnw

X-ray diffraction
2.2Å resolution

Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment with a gp41 MPER-derived peptide in a helical conformation

Released:
DOI: 10.2210/pdb3mnw/pdb
PDB entry 3mnw coloured by chain, front view.
PDB entry 3mnw coloured by chain, side view.
PDB entry 3mnw coloured by chain, top view.
Source organisms:
Entry authors: Nicely NI, Dennison SM, Kelsoe G, Liao H-X, Alam SM, Haynes BF

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
hetero hexamer
PDBe Complex ID:
PDB-CPX-137930 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Transmembrane protein gp41 Chain: P
Molecule details ›
Chain: P
Length: 21 amino acids
Theoretical weight: 2.5 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04578 (Residues: 652-671; Coverage: 2%)
Gene name: env
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 224 amino acids
Theoretical weight: 24.72 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8TCD0 (Residues: 21-55, 56-239; Coverage: 100%)
Sequence domains:
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chain: B
Molecule details ›
Chain: B
Length: 219 amino acids
Theoretical weight: 23.52 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: S6B291 (Residues: 20-241; Coverage: 49%)
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: C2221
Unit cell:
a: 43.753Å b: 160.989Å c: 141.055Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.181 0.253
Expression systems:
  • Not provided
  • Homo sapiens

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