Function and Biology

Crystal structure of the E130Y mutant of human soluble calcium-activated nucleotidase (SCAN) with calcium ion

Source organism: Homo sapiens
Biochemical function: nucleoside diphosphate phosphatase activity
Biological process: not assigned
Cellular component: not assigned

EC 3.6.1.6: Nucleoside diphosphate phosphatase

Reaction catalysed:
A nucleoside diphosphate + H(2)O = a nucleoside phosphate + phosphate
Systematic name:
Nucleoside-diphosphate phosphohydrolase
Alternative Name(s):
  • ADPase
  • Adenosine diphosphatase
  • Adenosinepyrophosphatase
  • CDPase
  • GDPase
  • Guanosine 5'-diphosphatase
  • Guanosine diphosphatase
  • IDPase
  • Inosine 5'-diphosphatase
  • Inosine diphosphatase
  • NDPase
  • Nucleoside 5'-diphosphatase
  • Nucleoside diphosphate phosphohydrolase
  • Nucleoside-diphosphatase
  • Thiaminpyrophosphatase
  • Type B nucleoside diphosphatase
  • Type L nucleoside diphosphatase
  • UDPase
  • Uridine 5'-diphosphatase
  • Uridine diphosphatase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF06079
Domain description: Apyrase
Occurring in:
  1. Soluble calcium-activated nucleotidase 1
The deposited structure of PDB entry 2h2u contains 2 copies of Pfam domain PF06079 (Apyrase) in Soluble calcium-activated nucleotidase 1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR036258
Domain description: Apyrase superfamily
Occurring in:
  1. Soluble calcium-activated nucleotidase 1
IPR009283
Domain description: Apyrase
Occurring in:
  1. Soluble calcium-activated nucleotidase 1

Structure domain

CATH CATH domain
2.120.10.100
Class: Mainly Beta
Architecture: 6 Propeller
Topology: Neuraminidase
Homology: Apyrase
Occurring in:
  1. Soluble calcium-activated nucleotidase 1
The deposited structure of PDB entry 2h2u contains 2 copies of CATH domain 2.120.10.100 (Neuraminidase) in Soluble calcium-activated nucleotidase 1. Showing 1 copy in chain B.