PDBe 2h2u

X-ray diffraction
2.4Å resolution

Crystal structure of the E130Y mutant of human soluble calcium-activated nucleotidase (SCAN) with calcium ion

Released:

Function and Biology Details

Reaction catalysed:
A nucleoside diphosphate + H(2)O = a nucleoside phosphate + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Soluble calcium-activated nucleotidase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 339 amino acids
Theoretical weight: 37.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WVQ1 (Residues: 69-401; Coverage: 83%)
Gene names: CANT1, SHAPY
Sequence domains: Apyrase
Structure domains: Neuraminidase

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P1
Unit cell:
a: 42.891Å b: 52.412Å c: 77.806Å
α: 100.94° β: 106.51° γ: 99.32°
R-values:
R R work R free
0.22 0.216 0.285
Expression system: Escherichia coli