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5-hydroxy-levulinic acid bound to Porphobilinogen synthase from Pseudomonas aeruginosa

X-ray diffraction
2.15Å resolution
PDB entry 2c13 coloured by chain, front view.
PDB entry 2c13 coloured by chain, side view.
PDB entry 2c13 coloured by chain, top view.
Source organism: Pseudomonas aeruginosa
Assembly composition:
homo octamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Delta-aminolevulinic acid dehydratase
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Multimeric state: homo octamer
Accessible surface area: 71032.69 Å2
Buried surface area: 59399.58 Å2
Dissociation area: 12,392.59 Å2
Dissociation energy (ΔGdiss): 49.48 kcal/mol
Dissociation entropy (TΔSdiss): 48.09 kcal/mol
Symmetry number: 8
PDBe Complex ID: PDB-CPX-176810

Macromolecules

Delta-aminolevulinic acid dehydratase
Chains: A, B
Length: 337 amino acids
Theoretical weight: 37.29 KDa
Source organism: Pseudomonas aeruginosa
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q59643 (Residues: 1-337; Coverage: 100%)
Gene names: PA5243, hemB
Pfam: Delta-aminolevulinic acid dehydratase
InterPro:
CATH: Aldolase class I
Delta-aminolevulinic acid dehydratase in PDB entry 2c13, assembly 1, front view.
Delta-aminolevulinic acid dehydratase in PDB entry 2c13, assembly 1, side view.
Delta-aminolevulinic acid dehydratase in PDB entry 2c13, assembly 1, top view.
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