› 2n2h

Solution NMR

Solution structure of Sds3 in complex with Sin3A

Released:
DOI: 10.2210/pdb2n2h/pdb
PDB entry 2n2h coloured by chain, ensemble of 20 models, front view.
PDB entry 2n2h coloured by chain, ensemble of 20 models, side view.
PDB entry 2n2h coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex.
Clark MD, Marcum R, Graveline R, Chan CW, Xie T, Chen Z, Ding Y, Zhang Y, Mondragón A, David G, Radhakrishnan I
Proc Natl Acad Sci U S A 112 E3669-78 (2015)
PMID: 26124119

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178787 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sin3 histone deacetylase corepressor complex component SDS3 Chain: A
Molecule details ›
Chain: A
Length: 27 amino acids
Theoretical weight: 3.13 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8BR65 (Residues: 205-228; Coverage: 7%)
Gene names: Sds3, Suds3
Paired amphipathic helix protein Sin3a Chain: B
Molecule details ›
Chain: B
Length: 125 amino acids
Theoretical weight: 14.7 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q60520 (Residues: 608-729; Coverage: 10%)
Gene names: Kiaa4126, Sin3a
Sequence domains: Sin3 family co-repressor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 83%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

8 review citations

How do lncRNAs regulate transcription?
Long et al. (2017)
7 more

9 mentions without citation

Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex.
Adams et al. (2018)
8 more