Domain

Histone deacetylase interacting domain (IPR013194)

Short name: HDAC_interact_dom

Domain relationships

None.

Description

This domain is found in the transcriptional repressor Sin3. It forms interactions with histone deacetylases [PMID: 12773392].

Budding yeast Sin3 is a component of both the Rpd3S and Rpd3L histone deacetylase complexes [PMID: 16314178]. In mammals there are two Sin3 paraologues, Sin3A and Sin3B. They forms the larger Sin3L/Rpd3L and the smaller Sin3S/Rpd3S complexes, both complexes rely largely on HDAC (histone deacetylase) activity to affect transcriptional repression. Sin3A and Sin3B may partition into the Sin3L/Rpd3L and Sin3S/Rpd3S complexes, respectively [PMID: 26124119].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam