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Crystal structure of project ID TT0268 from Thermus thermophilus HB8

Source organism: Thermus thermophilus HB8
Biochemical function: pentosyltransferase activity
Biological process: quinolinate catabolic process
Cellular component: cytoplasm

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EC 2.4.2.19: Nicotinate-nucleotide diphosphorylase (carboxylating)

Reaction catalysed:
Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
Systematic name:
Beta-nicotinate-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)
Alternative Name(s):
  • NAD pyrophosphorylase
  • Nicotinate mononucleotide pyrophosphorylase (carboxylating)
  • Nicotinate-nucleotide pyrophosphorylase (carboxylating)
  • Nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)
  • QAPRTase
  • Quinolinate phosphoribosyltransferase (decarboxylating)
  • Quinolinic acid phosphoribosyltransferase
  • Quinolinic phosphoribosyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01729
Domain description: Quinolinate phosphoribosyl transferase, C-terminal domain
Occurring in:
  1. nicotinate-nucleotide diphosphorylase (carboxylating)
The deposited structure of PDB entry 1x1o contains 3 copies of Pfam domain PF01729 (Quinolinate phosphoribosyl transferase, C-terminal domain) in nicotinate-nucleotide diphosphorylase (carboxylating). Showing 1 copy in chain A.

PF02749
Domain description: Quinolinate phosphoribosyl transferase, N-terminal domain
Occurring in:
  1. nicotinate-nucleotide diphosphorylase (carboxylating)
The deposited structure of PDB entry 1x1o contains 3 copies of Pfam domain PF02749 (Quinolinate phosphoribosyl transferase, N-terminal domain) in nicotinate-nucleotide diphosphorylase (carboxylating). Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004393
Domain description: Nicotinate-nucleotide pyrophosphorylase
Occurring in:
  1. nicotinate-nucleotide diphosphorylase (carboxylating)
IPR027277
Domain description: Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD
Occurring in:
  1. nicotinate-nucleotide diphosphorylase (carboxylating)
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. nicotinate-nucleotide diphosphorylase (carboxylating)
IPR036068
Domain description: Nicotinate phosphoribosyltransferase-like, C-terminal
Occurring in:
  1. nicotinate-nucleotide diphosphorylase (carboxylating)
IPR002638
Domain description: Quinolinate phosphoribosyl transferase, C-terminal
Occurring in:
  1. nicotinate-nucleotide diphosphorylase (carboxylating)
IPR022412
Domain description: Quinolinate phosphoribosyl transferase, N-terminal
Occurring in:
  1. nicotinate-nucleotide diphosphorylase (carboxylating)
IPR037128
Domain description: Quinolinate phosphoribosyl transferase, N-terminal domain superfamily
Occurring in:
  1. nicotinate-nucleotide diphosphorylase (carboxylating)

Structure domains

CATH CATH domains
3.90.1170.20
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aldehyde Oxidoreductase; domain 3
Homology: Quinolinate phosphoribosyl transferase, N-terminal domain
Occurring in:
  1. nicotinate-nucleotide diphosphorylase (carboxylating)
The deposited structure of PDB entry 1x1o contains 3 copies of CATH domain 3.90.1170.20 (Aldehyde Oxidoreductase; domain 3) in nicotinate-nucleotide diphosphorylase (carboxylating). Showing 1 copy in chain A.
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. nicotinate-nucleotide diphosphorylase (carboxylating)
The deposited structure of PDB entry 1x1o contains 3 copies of CATH domain 3.20.20.70 (TIM Barrel) in nicotinate-nucleotide diphosphorylase (carboxylating). Showing 1 copy in chain A.

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