Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD (IPR027277)

Short name: NadC/ModD

Overlapping homologous superfamilies

Family relationships


Proteins in this family includes nicotinate-nucleotide pyrophosphorylase (EC: and putative pyrophosphorylase ModD.

Nicotinate-nucleotide pyrophosphorylase is a type II phosphoribosyltransferase which provides the de novo source of nicotinate mononucleotide (NAMN) for NAD biosynthesis in both prokaryotes and eukaryotes [PMID: 6997723, PMID: 11876660]. Human quinolinate phosphoribosyltransferase (also known as hQPRTase) is involved in the catabolism of quinolinic acid (QA) [PMID: 17868694]. Elevation of QA levels in the brain has been linked to the pathogenesis of a range of neurodegenerative disorders [PMID: 3159462].

ModD is found with molybdenum transport genes modABC in Rhodobacter capsulatus. However, disruption of modD causes only a 4-fold (rather than 500-fold for modA, modB, modC) change in the external molybdenum concentration required to suppress an alternative nitrogenase [PMID: 8491722]. ModD proteins are highly similar to nicotinate-nucleotide pyrophosphorylase (also called quinolinate phosphoribosyltransferase). Their function is unknown.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.