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CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE REDUCTASE MODULE AT 2.3 A RESOLUTION.

Source organism: Rattus norvegicus
Biochemical function: oxidoreductase activity
Biological process: not assigned
Cellular component: not assigned

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EC 1.14.13.39: Nitric-oxide synthase (NADPH)

Reaction catalysed:
(1a) 2 L-arginine + 2 NADPH + 2 O(2) = 2 N(omega)-hydroxy-L-arginine + 2 NADP(+) + 2 H(2)O
Systematic name:
L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
Alternative Name(s):
  • Endothelium-derived relaxation factor-forming enzyme
  • Endothelium-derived relaxing factor synthase
  • NADPH-diaphorase
  • NO synthase
  • NOS (gene name)
  • Nitric oxide synthetase
  • Nitric-oxide synthetase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00175
Domain description: Oxidoreductase NAD-binding domain
Occurring in:
  1. Nitric oxide synthase 1
The deposited structure of PDB entry 1tll contains 2 copies of Pfam domain PF00175 (Oxidoreductase NAD-binding domain ) in Nitric oxide synthase 1. Showing 1 copy in chain A.

PF00667
Domain description: FAD binding domain
Occurring in:
  1. Nitric oxide synthase 1
The deposited structure of PDB entry 1tll contains 2 copies of Pfam domain PF00667 (FAD binding domain) in Nitric oxide synthase 1. Showing 1 copy in chain A.

PF00258
Domain description: Flavodoxin
Occurring in:
  1. Nitric oxide synthase 1
The deposited structure of PDB entry 1tll contains 2 copies of Pfam domain PF00258 (Flavodoxin) in Nitric oxide synthase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001709
Domain description: Flavoprotein pyridine nucleotide cytochrome reductase
Occurring in:
  1. Nitric oxide synthase 1
IPR001094
Domain description: Flavodoxin-like
Occurring in:
  1. Nitric oxide synthase 1
IPR039261
Domain description: Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Occurring in:
  1. Nitric oxide synthase 1
IPR008254
Domain description: Flavodoxin/nitric oxide synthase
Occurring in:
  1. Nitric oxide synthase 1
IPR029039
Domain description: Flavoprotein-like superfamily
Occurring in:
  1. Nitric oxide synthase 1
IPR001433
Domain description: Oxidoreductase FAD/NAD(P)-binding
Occurring in:
  1. Nitric oxide synthase 1
IPR017927
Domain description: FAD-binding domain, ferredoxin reductase-type
Occurring in:
  1. Nitric oxide synthase 1
IPR003097
Domain description: Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
Occurring in:
  1. Nitric oxide synthase 1
IPR023173
Domain description: NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
Occurring in:
  1. Nitric oxide synthase 1
IPR017938
Domain description: Riboflavin synthase-like beta-barrel
Occurring in:
  1. Nitric oxide synthase 1

Structure domains

CATH CATH domains
2.40.30.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Elongation Factor Tu (Ef-tu); domain 3
Homology: Translation factors
Occurring in:
  1. Nitric oxide synthase 1
The deposited structure of PDB entry 1tll contains 2 copies of CATH domain 2.40.30.10 (Elongation Factor Tu (Ef-tu); domain 3) in Nitric oxide synthase 1. Showing 1 copy in chain A.
1.20.990.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: NADPH-cytochrome p450 Reductase; Chain A, domain 3
Homology: NADPH-cytochrome p450 Reductase; Chain A, domain 3
Occurring in:
  1. Nitric oxide synthase 1
The deposited structure of PDB entry 1tll contains 2 copies of CATH domain 1.20.990.10 (NADPH-cytochrome p450 Reductase; Chain A, domain 3) in Nitric oxide synthase 1. Showing 1 copy in chain A.
3.40.50.80
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module
Occurring in:
  1. Nitric oxide synthase 1
The deposited structure of PDB entry 1tll contains 2 copies of CATH domain 3.40.50.80 (Rossmann fold) in Nitric oxide synthase 1. Showing 1 copy in chain A.
3.40.50.360
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Nitric oxide synthase 1
The deposited structure of PDB entry 1tll contains 2 copies of CATH domain 3.40.50.360 (Rossmann fold) in Nitric oxide synthase 1. Showing 1 copy in chain A.
SCOP SCOP annotations
52365
Class: Alpha and beta proteins (a/b)
Fold: Ferredoxin reductase-like, C-terminal NADP-linked domain
Superfamily: Ferredoxin reductase-like, C-terminal NADP-linked domain
Occurring in:
  1. Nitric oxide synthase 1
The deposited structure of PDB entry 1tll contains 2 copies of SCOP domain 52365 (NADPH-cytochrome p450 reductase-like) in Nitric oxide synthase 1. Showing 1 copy in chain A.
50438
Class: All beta proteins
Fold: Reductase/isomerase/elongation factor common domain
Superfamily: Riboflavin synthase domain-like
Occurring in:
  1. Nitric oxide synthase 1
The deposited structure of PDB entry 1tll contains 2 copies of SCOP domain 50438 (NADPH-cytochrome p450 reductase FAD-binding domain-like) in Nitric oxide synthase 1. Showing 1 copy in chain A.
52231
Class: Alpha and beta proteins (a/b)
Fold: Flavodoxin-like
Superfamily: Flavoproteins
Occurring in:
  1. Nitric oxide synthase 1
The deposited structure of PDB entry 1tll contains 2 copies of SCOP domain 52231 (Cytochrome p450 reductase N-terminal domain-like) in Nitric oxide synthase 1. Showing 1 copy in chain A.

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