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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE-CONTAINING HEXA-PEPTIDE (DADEPYL-NH2)

X-ray diffraction
2.6Å resolution
PDB entry 1ptu coloured by chain, front view.
PDB entry 1ptu coloured by chain, side view.
PDB entry 1ptu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 1 and peptide
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Multimeric state: hetero tetramer
Accessible surface area: 25315.11 Å2
Buried surface area: 3396.87 Å2
Dissociation area: 679.55 Å2
Dissociation energy (ΔGdiss): -10.72 kcal/mol
Dissociation entropy (TΔSdiss): 13.42 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-148268

Macromolecules

Tyrosine-protein phosphatase non-receptor type 1
Chain: A
Length: 321 amino acids
Theoretical weight: 37.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18031 (Residues: 1-321; Coverage: 74%)
Gene names: PTP1B, PTPN1
Pfam: Protein-tyrosine phosphatase
InterPro:
CATH: Protein tyrosine phosphatase superfamily
SCOP: Higher-molecular-weight phosphotyrosine protein phosphatases
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 1ptu, assembly 1, front view.
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 1ptu, assembly 1, side view.
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 1ptu, assembly 1, top view.
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PHOSPHOTYROSINE-CONTAINING HEXA-PEPTIDE
Chain: B
Length: 7 amino acids
Theoretical weight: 803 Da
Source organism: Homo sapiens
Expression system: Not provided
PHOSPHOTYROSINE-CONTAINING HEXA-PEPTIDE in PDB entry 1ptu, assembly 1, front view.
PHOSPHOTYROSINE-CONTAINING HEXA-PEPTIDE in PDB entry 1ptu, assembly 1, side view.
PHOSPHOTYROSINE-CONTAINING HEXA-PEPTIDE in PDB entry 1ptu, assembly 1, top view.
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