Function and Biology

Crystal structure of mouse ARF1 (delta17-Q71L), GTP form

Source organism: Mus musculus
Biochemical function: phospholipase D activator activity
Biological process: mitotic cleavage furrow ingression
Cellular component: glutamatergic synapse

EC 3.6.5.2: Small monomeric GTPase

Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (cell-regulating)

Sequence family

Pfam Protein family (Pfam)
PF00025
Domain description: ADP-ribosylation factor family
Occurring in:
  1. ADP-ribosylation factor 1
The deposited structure of PDB entry 1o3y contains 2 copies of Pfam domain PF00025 (ADP-ribosylation factor family) in ADP-ribosylation factor 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006689
Domain description: Small GTPase superfamily, ARF/SAR type
Occurring in:
  1. ADP-ribosylation factor 1
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. ADP-ribosylation factor 1
IPR045872
Domain description: ADP-ribosylation factor 1-5
Occurring in:
  1. ADP-ribosylation factor 1
IPR005225
Domain description: Small GTP-binding protein domain
Occurring in:
  1. ADP-ribosylation factor 1
IPR024156
Domain description: Small GTPase superfamily, ARF type
Occurring in:
  1. ADP-ribosylation factor 1

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. ADP-ribosylation factor 1
The deposited structure of PDB entry 1o3y contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in ADP-ribosylation factor 1. Showing 1 copy in chain A.
SCOP SCOP annotation
52592
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. ADP-ribosylation factor 1
The deposited structure of PDB entry 1o3y contains 2 copies of SCOP domain 52592 (G proteins) in ADP-ribosylation factor 1. Showing 1 copy in chain A.