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Structure of methylene-tetrahydromethanopterin dehydrogenase from Methylobacterium extorquens AM1 complexed with NADP

Source organism: Methylorubrum extorquens AM1
Biochemical function: oxidoreductase activity
Biological process: formaldehyde catabolic process
Cellular component: cytoplasm

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EC 1.5.1.5: Methylenetetrahydrofolate dehydrogenase (NADP(+))

Reaction catalysed:
5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH
Systematic name:
5,10-methylenetetrahydrofolate:NADP(+) oxidoreductase
Alternative Name(s):
  • 5,10-methylenetetrahydrofolate dehydrogenase
  • 5,10-methylenetetrahydrofolate:NADP oxidoreductase
  • Methylenetetrahydrofolate dehydrogenase
  • Methylenetetrahydrofolate dehydrogenase (NADP)
  • N(5),N(10)-methylenetetrahydrofolate dehydrogenase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF09176
Domain description: Methylene-tetrahydromethanopterin dehydrogenase, N-terminal
Occurring in:
  1. Bifunctional protein MdtA
The deposited structure of PDB entry 1lua contains 3 copies of Pfam domain PF09176 (Methylene-tetrahydromethanopterin dehydrogenase, N-terminal) in Bifunctional protein MdtA. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Bifunctional protein MdtA
IPR035015
Domain description: Methylene tetrahydromethanopterin dehydrogenase, NADP-binding domain
Occurring in:
  1. Bifunctional protein MdtA
IPR015259
Domain description: Methylene-tetrahydromethanopterin dehydrogenase, N-terminal
Occurring in:
  1. Bifunctional protein MdtA
IPR046346
Domain description: Aminoacid dehydrogenase-like, N-terminal domain superfamily
Occurring in:
  1. Bifunctional protein MdtA
IPR037089
Domain description: Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain superfamily
Occurring in:
  1. Bifunctional protein MdtA

Structure domains

CATH CATH domains
3.40.50.10280
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain
Occurring in:
  1. Bifunctional protein MdtA
The deposited structure of PDB entry 1lua contains 3 copies of CATH domain 3.40.50.10280 (Rossmann fold) in Bifunctional protein MdtA. Showing 1 copy in chain A.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Bifunctional protein MdtA
The deposited structure of PDB entry 1lua contains 3 copies of CATH domain 3.40.50.720 (Rossmann fold) in Bifunctional protein MdtA. Showing 1 copy in chain A.
SCOP SCOP annotations
51883
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. Bifunctional protein MdtA
The deposited structure of PDB entry 1lua contains 3 copies of SCOP domain 51883 (Aminoacid dehydrogenase-like, C-terminal domain) in Bifunctional protein MdtA. Showing 1 copy in chain A.
82333
Class: Alpha and beta proteins (a/b)
Fold: Aminoacid dehydrogenase-like, N-terminal domain
Superfamily: Aminoacid dehydrogenase-like, N-terminal domain
Occurring in:
  1. Bifunctional protein MdtA
The deposited structure of PDB entry 1lua contains 3 copies of SCOP domain 82333 (Methylene-tetrahydromethanopterin dehydrogenase) in Bifunctional protein MdtA. Showing 1 copy in chain A.

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