› › Function and Biology

First Structural Evidence of a Specific Inhibition of Phospholipase A2 by Vitamin E and its Implications in Inflammation: Crystal Structure of the Complex Formed between Phospholipase A2 and Vitamin E at 1.8 A Resolution.

Source organism: Daboia russelii pulchella
Biochemical function: toxin activity
Biological process: arachidonic acid secretion
Cellular component: extracellular region

Quick links

EC 3.1.1.4: Phospholipase A(2)

Reaction catalysed:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Systematic name:
Phosphatidylcholine 2-acylhydrolase
Alternative Name(s):
  • Lecithinase A
  • Phosphatidase
  • Phosphatidolipase
  • Phospholipase A
  • Phospholipase A2

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00068
Domain description: Phospholipase A2
Occurring in:
  1. Basic phospholipase A2 VRV-PL-VIIIa
The deposited structure of PDB entry 1kpm contains 2 copies of Pfam domain PF00068 (Phospholipase A2) in Basic phospholipase A2 VRV-PL-VIIIa. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001211
Domain description: Phospholipase A2
Occurring in:
  1. Basic phospholipase A2 VRV-PL-VIIIa
IPR016090
Domain description: Phospholipase A2 domain
Occurring in:
  1. Basic phospholipase A2 VRV-PL-VIIIa
IPR036444
Domain description: Phospholipase A2 domain superfamily
Occurring in:
  1. Basic phospholipase A2 VRV-PL-VIIIa
IPR033112
Domain description: Phospholipase A2, aspartic acid active site
Occurring in:
  1. Basic phospholipase A2 VRV-PL-VIIIa
IPR033113
Domain description: Phospholipase A2, histidine active site
Occurring in:
  1. Basic phospholipase A2 VRV-PL-VIIIa

Structure domain

CATH CATH domain
1.20.90.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Phospholipase A2
Homology: Phospholipase A2 domain
Occurring in:
  1. Basic phospholipase A2 VRV-PL-VIIIa
The deposited structure of PDB entry 1kpm contains 2 copies of CATH domain 1.20.90.10 (Phospholipase A2) in Basic phospholipase A2 VRV-PL-VIIIa. Showing 1 copy in chain A.
SCOP SCOP annotation
48623
Class: All alpha proteins
Fold: Phospholipase A2, PLA2
Superfamily: Phospholipase A2, PLA2
Occurring in:
  1. Basic phospholipase A2 VRV-PL-VIIIa
The deposited structure of PDB entry 1kpm contains 2 copies of SCOP domain 48623 (Vertebrate phospholipase A2) in Basic phospholipase A2 VRV-PL-VIIIa. Showing 1 copy in chain A.

Quick links