Domain

Phospholipase A2 domain (IPR016090)

Short name: PLipase_A2_dom

Domain relationships

None.

Description

This entry represents eukaryotic and prokaryotic phospholipase A2 enzymes (PLA2; EC:3.1.1.4), small lipolytic enzymes that releases fatty acids from the second carbon group of glycerol. These enzymes enable the of fatty acids and lysophospholipid by hydrolysing the 2-ester bond of 1,2-diacyl-3-sn-phosphoglycerides.

The phospholipase domain adopts an alpha-helical secondary structure, consisting of five alpha-helices and two helical segments [PMID: 11897785, PMID: 12161451]. In eukaryotes, PLAS plays a pivotal role in the biosynthesis of prostaglandin and other mediators of inflammation.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
Pfam
SUPERFAMILY
SMART