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MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3

Source organism: Homo sapiens
Biochemical function: tumor necrosis factor receptor binding
Biological process: regulation of defense response to virus
Cellular component: not assigned

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EC 2.3.2.27: RING-type E3 ubiquitin transferase

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
  • RING E3 ligase
  • Ubiquitin transferase RING E3

GO terms

Sequence family

Pfam Protein family (Pfam)
PF21355
Domain description: TRAF/meprin, MATH domain
Occurring in:
  1. TNF receptor-associated factor 3
The deposited structure of PDB entry 1flk contains 2 copies of Pfam domain PF21355 (TRAF/meprin, MATH domain) in TNF receptor-associated factor 3. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002083
Domain description: MATH/TRAF domain
Occurring in:
  1. TNF receptor-associated factor 3
IPR037304
Domain description: TNF receptor-associated factor 3, MATH domain
Occurring in:
  1. TNF receptor-associated factor 3
IPR008974
Domain description: TRAF-like
Occurring in:
  1. TNF receptor-associated factor 3

Structure domain

CATH CATH domain
2.60.210.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Homology: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Occurring in:
  1. TNF receptor-associated factor 3
The deposited structure of PDB entry 1flk contains 2 copies of CATH domain 2.60.210.10 (Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A) in TNF receptor-associated factor 3. Showing 1 copy in chain A.
SCOP SCOP annotations
49600
Class: All beta proteins
Fold: TRAF domain-like
Superfamily: TRAF domain-like
Occurring in:
  1. TNF receptor-associated factor 3
The deposited structure of PDB entry 1flk contains 2 copies of SCOP domain 49600 (MATH domain) in TNF receptor-associated factor 3. Showing 1 copy in chain A.
57954
Class: Coiled coil proteins
Fold: Parallel coiled-coil
Superfamily: Trimerization domain of TRAF
Occurring in:
  1. TNF receptor-associated factor 3
The deposited structure of PDB entry 1flk contains 2 copies of SCOP domain 57954 (Trimerization domain of TRAF) in TNF receptor-associated factor 3. Showing 1 copy in chain A.

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