TRAF3, MATH domain (IPR037304)

Short name: TRAF3_MATH

Overlapping homologous superfamilies


Domain relationships


Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated protein (MAP) kinase activation and non-canonical nuclear factor-kB signalling [PMID: 21660053]. It is a critical regulator of both innate and adaptive immune responses [PMID: 17633016]. TRAF3 plays a role in the regulation of B-cell survival [PMID: 18313334], in the regulation of antiviral responses [PMID: 16306936], and in T-cell dependent immune responses [PMID: 8934568]. It is required for normal antibody isotype switching from IgM to IgG [PMID: 19228877]. Differences in the ubiquitination of TRAF3 are the key to the selective production of type I interferons versus proinflammatory cytokines [PMID: 19898473].

TRAF3 contains a RING finger domain, five zinc finger domains, and a TRAF domain. The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded beta-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors [PMID: 15585864].

GO terms

Biological Process

GO:0008063 Toll signaling pathway
GO:0045087 innate immune response
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0001817 regulation of cytokine production
GO:0050688 regulation of defense response to virus
GO:0033209 tumor necrosis factor-mediated signaling pathway

Molecular Function

GO:0005164 tumor necrosis factor receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.