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COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-1

X-ray diffraction
2.8Å resolution
PDB entry 1bkd coloured by chain, front view.
PDB entry 1bkd coloured by chain, side view.
PDB entry 1bkd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero octamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Son of sevenless homolog 1 and GTPase HRas, N-terminally processed
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Multimeric state: hetero octamer
Accessible surface area: 108516.47 Å2
Buried surface area: 21197.42 Å2
Dissociation area: 4,291.32 Å2
Dissociation energy (ΔGdiss): -8.1 kcal/mol
Dissociation entropy (TΔSdiss): 47.66 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-133984

Macromolecules

GTPase HRas, N-terminally processed
Chain: R
Length: 166 amino acids
Theoretical weight: 18.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01112 (Residues: 1-166; Coverage: 88%)
Gene names: HRAS, HRAS1
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
SCOP: G proteins
GTPase HRas, N-terminally processed in PDB entry 1bkd, assembly 1, front view.
GTPase HRas, N-terminally processed in PDB entry 1bkd, assembly 1, side view.
GTPase HRas, N-terminally processed in PDB entry 1bkd, assembly 1, top view.
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Son of sevenless homolog 1
Chain: S
Length: 477 amino acids
Theoretical weight: 56.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q07889 (Residues: 568-1044; Coverage: 36%)
Gene name: SOS1
Pfam:
InterPro:
CATH:
SCOP: Ras GEF
Son of sevenless homolog 1 in PDB entry 1bkd, assembly 1, front view.
Son of sevenless homolog 1 in PDB entry 1bkd, assembly 1, side view.
Son of sevenless homolog 1 in PDB entry 1bkd, assembly 1, top view.
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