Function and Biology Details
Reactions catalysed:
Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
- DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain
- Alkaline-phosphatase-like, core domain superfamily
- ENPP1-3/EXOG-like, endonuclease/phosphodiesterase domain
- His-Me finger superfamily
- DNA/RNA non-specific endonuclease superfamily
- Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161320 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Molecule details ›
Chains: A, B
Length: 749 amino acids
Theoretical weight: 85.37 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
Sequence domains: Type I phosphodiesterase / nucleotide pyrophosphatase
Length: 749 amino acids
Theoretical weight: 85.37 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
- Canonical:
P97675 (Residues: 140-875; Coverage: 84%)
Sequence domains: Type I phosphodiesterase / nucleotide pyrophosphatase
Ligands and Environments
Experiments and Validation Details
X-ray source:
BESSY BEAMLINE 14.1
Spacegroup:
P21
Expression system: Homo sapiens
