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Overview
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Pathways & interactions
Extracellular Endonuclease, subunit A (IPR020821)
Short name: Extracellular_endonuc_su_A
Overlapping homologous superfamilies
None.
Domain relationships
- DNA/RNA non-specific endonuclease (IPR001604)
- Extracellular Endonuclease, subunit A (IPR020821)
Description
A family of bacterial and eukaryotic endonucleases EC:3.1.30 share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity. A histidine has been shown [PMID: 8078761] to be essential for the activity of the Serratia marcescens nuclease. This residue is located in a conserved region which also contains an aspartic acid residue that could be implicated in the binding of the divalent ion.
GO terms
Biological Process
No terms assigned in this category.
Molecular Function
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0003676 nucleic acid binding
Cellular Component
No terms assigned in this category.
Contributing signatures
- SM00477 (NUC)