› 1za6

X-ray diffraction
2.8Å resolution

The structure of an antitumor CH2-domain-deleted humanized antibody

Released:
DOI: 10.2210/pdb1za6/pdb
PDB entry 1za6 coloured by chain, front view.
PDB entry 1za6 coloured by chain, side view.
PDB entry 1za6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of an antitumor C(H)2-domain-deleted humanized antibody.
Larson SB, Day JS, Glaser S, Braslawsky G, McPherson A
J Mol Biol 348 1177-90 (2005)
PMID: 15854653

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
hetero tetramer (preferred)
hetero hexadecamer
hetero octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-212367 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IGG Light chain Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 220 amino acids
Theoretical weight: 24.21 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 344 amino acids
Theoretical weight: 36.95 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q6GMX6 (Residues: 20-77, 78-465; Coverage: 77%)
Gene name: IGH@
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21212
Unit cell:
a: 82.54Å b: 224.2Å c: 166.59Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.246 0.246 0.296
Expression system: Cricetulus griseus

Quick links

Citations

2 review citations

Molecular probes for the in vivo imaging of cancer.
Alford et al. (2009)
1 more

4 mentions without citation

Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody.
Prabakaran et al. (2006)
3 more