GET /metagenomics/api/v1/samples/SRS2719596/studies?format=api
HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept
{
"links": {
"first": "https://www.ebi.ac.uk/metagenomics/api/v1/samples/SRS2719596/studies?format=api&page=1",
"last": "https://www.ebi.ac.uk/metagenomics/api/v1/samples/SRS2719596/studies?format=api&page=1",
"next": null,
"prev": null
},
"data": [
{
"type": "studies",
"id": "MGYS00006499",
"attributes": {
"accession": "MGYS00006499",
"bioproject": "PRJNA419860",
"samples-count": 194,
"is-private": false,
"last-update": "2023-09-25T13:53:45",
"secondary-accession": "SRP125799",
"centre-name": "University of Geneva",
"public-release-date": null,
"study-abstract": "Commensal microbiota play an important role in many physiological processes. Importantly, they pose a natural threshold to colonization with pathogenic bacteria by direct competition. Here we show that acute infection of the lung with influenza A viruses causes elimination of a substantial proportion of bacteria from the small intestine. This weakens the natural shield against pathogenic bacteria and renders the intestinal epithelium vulnerable for invading bacteria. We further show that influenza A virus infection up-regulates the activity of Paneth cells a major source of antimicrobial peptides in the small intestine. This suggests that influenza A viruses affect a host mechanism of microbiota regulation to cause bacterial depletion in the small intestine. Surprisingly, the same mechanism does not apply in the respiratory tract, where influenza A virus infection causes subtle qualitative but not quantitative changes in the commensal microbiota. Overall, our date provide the first description of microbiota dynamics in an acute infection animal model.",
"study-name": "Lung microbiota of C57BL/6J mice (Mus Musculus) Raw sequence reads",
"data-origination": "HARVESTED"
},
"relationships": {
"publications": {
"links": {
"related": "https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00006499/publications?format=api"
}
},
"downloads": {
"links": {
"related": "https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00006499/downloads?format=api"
}
},
"samples": {
"links": {
"related": "https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00006499/samples?format=api"
}
},
"biomes": {
"links": {
"related": "https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00006499/biomes?format=api"
},
"data": [
{
"type": "biomes",
"id": "root:Host-associated:Human:Respiratory system:Pulmonary system:Lung",
"links": {
"self": "https://www.ebi.ac.uk/metagenomics/api/v1/biomes/root:Host-associated:Human:Respiratory%20system:Pulmonary%20system:Lung?format=api"
}
}
]
},
"analyses": {
"links": {
"related": "https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00006499/analyses?format=api"
}
},
"geocoordinates": {
"links": {
"related": "https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00006499/geocoordinates?format=api"
}
}
},
"links": {
"self": "https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00006499?format=api"
}
}
],
"meta": {
"pagination": {
"page": 1,
"pages": 1,
"count": 1
}
}
}