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"last-update": "2024-01-08T09:40:05",
"secondary-accession": "SRP070699",
"centre-name": "Technical University of Denmark",
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"study-abstract": "Little is known about how colonic transit time relates to human colonic metabolism, and its importance for host health, although stool consistency, a proxy for colonic transit time, has recently been negatively associated with gut microbial richness. Here we show that colonic transit time in humans, assessed using radiopaque markers, is associated with overall gut microbial composition, diversity and metabolism. We find that a long colonic transit time associates with high microbial richness and is accompanied by a shift in colonic metabolism from carbohydrate fermentation to protein catabolism as reflected by microbial metabolites in urine, which results in a number of deleterious protein-derived metabolites. Additionally, longer colonic transit time correlates with metabolites reflecting reduced renewal of the colonic mucosa. Together, this suggests that high gut microbial richness does not per se imply a healthy gut microbial ecosystem, and contributes to the understanding of the aetiology of diseases where increased transit time is a risk factor.",
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