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"bioproject": "PRJEB11686",
"samples-count": 14,
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"last-update": "2016-01-20T14:12:06",
"secondary-accession": "ERP013093",
"centre-name": "OREGON STATE UNIVERSITY , CORVALLIS, OREGON, UNITED STATES",
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"study-abstract": "Marine diseases are becoming more frequent, and tools for identifying pathogens and disease reservoirs are needed to help prevent and mitigate epizootics. Meta-transcriptomics provides insights into disease etiology by cataloguing and comparing sequences from suspected pathogens. This method is a powerful approach to simultaneously evaluate both the viral and bacterial communities, but few studies have?applied this technique in marine systems.?In 2009 seven harbor seals,?Phoca vitulina,?stranded along the California coast from a similar brain disease of?unknown cause of death (UCD). We evaluated the differences between the virome and microbiome of UCDs and harbor seals with known causes of death. Here we determined that UCD stranded animals had no viruses in their brain tissue. However, in the bacterial community, we identified?Burkholderia?and?Coxiella burnetii?as important pathogens associated with this stranding event.?Burkholderia?were 100% prevalent and ~2.8 log2 fold more abundant in the UCD animals. Further, while?C. burnetii?was found in only 35.7% of all samples, it was highly abundant (~94% of the total microbial community) in a single individual. In this harbor seal, C. burnetii?showed high transcription rates of invading and translation genes, implicating it in the pathogenesis of this animal. Based on these data we propose that?Burkholderia?taxa and?C. burnetii?are potentially important opportunistic neurotropic pathogens in UCD stranded harbor seals.",
"study-name": "Brain meta-transcriptomics from harbor seals to infer the role of the microbiome and virome in a stranding event",
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