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"accession": "MGYS00001695",
"bioproject": "PRJEB9034",
"is-private": false,
"last-update": "2017-04-13T11:16:11",
"secondary-accession": "ERP010088",
"centre-name": "ABERSYTWYTH UNIVERSITY",
"public-release-date": null,
"study-abstract": "Chronic Obstructive Pulmonary Disease (COPD) may worsen with microbial changes in the respiratory tract but studies into taxonomic structure of the COPD lung microbiome have yielded equivocal results. This may reflect the poor resolving power of taxonomic classification when only based 16S rRNA amplicon sequencing. We here report the metagenomic characterisation of COPD microbiome to more accurately reveal its species-level structure and functional capacity. The bacterial metagenomes within sputum samples from eight COPD patients and ten ?healthy? smokers (Controls) were sequenced and suggested increases in the abundance of bacterial species, particularly within Streptococcus in COPD. The functional capacity of the COPD lung microbiome indicated an increased capacity for bacterial growth, which could be an important feature in bacterial-associated acute exacerbations. Regression analyses correlated COPD severity (FEV1 % of predicted) with differences in the abundance of Streptococcus pneumonia and functional classifications related to a reduced capacity for bacterial sialic acid metabolism. Neither of these lung microbiome characteristics correlated with patient age or smoking pack history, further suggesting an association with COPD pathology. This study suggests that the COPD lung microbiome could be used in patient risk stratification and in identifying novel monitoring and treatment methods.",
"study-name": "Metagenomic analysis of the upper bronchial tract microbiome in patients with chronic obstructive pulmonary disease and 'healthy' smoker controls",
"data-origination": "SUBMITTED"
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