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"last-update": "2016-09-27T09:43:05",
"secondary-accession": "ERP010838",
"centre-name": "Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine",
"public-release-date": null,
"study-abstract": "Obesity, diabetes and metabolic syndrome are the results of complex interactions between genetic and environmental factors, including the gut microbiota. To dissect interactions between the gut microbiota, diet and genetic background, we utilized three inbred strains of mice, which differ in development of obesity and metabolic syndrome, plus three derivative lines generated by breeding these strains in a common environment. Analysis of metabolic parameters and gut microbiota in the inbred strains and their environmentally normalized derivatives revealed strong interactions between the microbiota, diet, environmental history and metabolic phenotypes. Some phenotypes could be transferred to germ-free recipient animals by fecal transplant. Strong strain-dependent and strain-independent correlations were found between specific microbes and metabolic phenotypes. Environmental reprogramming of the microbiota resulted in one obesity-prone strain becoming obesity-resistant. Thus, in mice, development of obesity/metabolic syndrome is the result of strong interactions between the gut microbiota, host genetics and diet. In permissive genetic backgrounds, environmental reprograming of the microbiota can ameliorate development of metabolic syndrome.",
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