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"study-abstract": "The Third Party Annotation (TPA) assembly was derived from the primary whole genome shotgun (WGS) data set: PRJEB8249. This project includes samples from the following biomes: root:Host-associated:Human:Digestive system:Large intestine.",
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"study-abstract": "Bariatric surgery is the most effective procedure for the treatment of obesity. Given the role of the gut microbiota in regulating host metabolism and adiposity, we investigated the long-term effects of bariatric surgery on the human gut metagenome in patients randomized to Roux-en-Y gastric bypass and vertical banded gastroplasty. Genera of the Proteobacteria were specifically enriched after bypass, and the abundance of genes for fatty acid metabolism, nitrogen metabolism and two-component systems was increased after both procedures nine years after surgery. Through colonization of germ-free mice with stools from the patients we demonstrated that the altered gut microbiota promoted reduced fat deposition in recipient mice. Recipients of bypass microbiota also had a lower respiratory quotient, indicating decreased utilization of carbohydrates as fuel. Our results suggest that the gut microbiota may play a direct role in the reduction of adiposity observed after bariatric surgery.",
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