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"bioproject": "PRJEB7112",
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"last-update": "2016-01-20T14:12:06",
"secondary-accession": "ERP006800",
"centre-name": "WEIZMANN INSTITUE OF SCIENCE",
"public-release-date": null,
"study-abstract": "All domains of life feature diverse molecular clock machineries that synchronize physiological processes to diurnal environmental fluctuations. However, no mechanisms are known to cross-regulate prokaryotic and eukaryotic circadian rhythms in multi-kingdom ecosystems. Here, we show that the intestinal microbiota, in both mice and humans, exhibits diurnal oscillations that are influenced by feeding rhythms, leading to time-specific compositional and functional profiles over the course of a day. Ablation of host molecular clock components or induction of jet lag leads to aberrant microbiota diurnal fluctuations and dysbiosis, driven by impaired feeding rhythmicity. Consequently, jet lag-induced dysbiosis in both mice and humans promotes glucose intolerance and obesity that are transferrable to germ-free mice upon fecal transplantation. Together, these findings provide the first evidence of coordinated meta-organism diurnal rhythmicity, and offer a microbiome-dependent mechanism for common metabolic disturbances in humans with aberrant circadian rhythms, such as those documented in shift workers and frequent flyers.",
"study-name": "Trans-kingdom control of microbiota diurnal oscillations promotes metabolic homeostasis",
"data-origination": "SUBMITTED"
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