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"study-abstract": "It is well established that the gastrointestinal (GI) microbiota regulate immune responses to GI pathogens. In particular, data from our group and others demonstrate that immune-modulatory GI microbes promote both immunopathology from, and facilitate chronic infection with, GI helminths. A deeper understanding of the mechanisms which govern these interactions will pave the way to designing novel approaches to helminth control, aimed at promoting an optimal immune response to infection whilst limiting pathology. Here we systematically described the impact of helminth infection on the GI microbiota in a herbivore-helminth system by comparing GI microbiota between acutely and chronically infected equine livestock and uninfected controls; and furthermore, we triangulated this data by profiling luminal and mucosal microbiota taken from throughout the GI tract at post-mortem in infected versus uninfected horses. The results revealed similarities between acute helminth infection models in mice and equines, suggesting that helminths may employ ubiquitous mechanisms in regulating host gut microbiota. Furthermore, the microbial signature of helminth infection was distinctly different between acutely and chronically infected animals, indicating that host adaptive immunity plays an important role in helminth-microbiota interactions. At post-mortem, data supported that from chronically infected animals, and also showed that the most profound impact of infection upon the GI microbiota was a significant down-regulation of methanogen populations. The implications of this finding for helminth control in the context of climate change will be discussed.Authors: Peachey L, Bull K, Jenkins T, Cantacessi C",
"study-name": "The impact of helminth infection on the mucosal and luminal GI microbiota of the horse",
"data-origination": "SUBMITTED"
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