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"last-update": "2024-01-08T13:29:07",
"secondary-accession": "ERP006059",
"centre-name": "CCME-COLORADO",
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"study-abstract": "Background,disturbance to human microbiota has been associated with numerous pathologies. Yet, we lack a comprehensive understanding for how human health and lifestyle affect the dynamics of human-associated microbial communities. Results, we link over 10,000 longitudinal measurements of host wellness and action to the daily gut and salivary microbiota dynamics of two individuals over the course of one year. These time-series show overall microbial communities to be stable for months. However, rare events in each of the subjects life rapidly and broadly impacted microbiota dynamics. Travel from the developed to the developing world in one subject led to a nearly two-fold increase in the Bacteroidetes to Firmicutes ratio, which reversed upon return. Enteric infection in the other subject resulted in the permanent decline of most gut bacterial taxa, which were replaced by genetically-similar species. Still, even during periods of overall community stability, we could associate the dynamics of select microbial taxa to specific host behaviors. Most prominently, changes in host fiber intake correlated with next-day abundance changes among 15 percent of gut microbiota members.Conclusions,our findings suggest that although human-associated microbial communities are generally stable, they can be quickly and profoundly altered by common human actions and experiences.",
"study-name": "Host lifestyle affects human microbiota on daily timescales",
"data-origination": "SUBMITTED"
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