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"accession": "MGYS00002188",
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"last-update": "2018-02-05T09:54:27",
"secondary-accession": "ERP005509",
"centre-name": "UNIVERSITY OF WATERLOO",
"public-release-date": null,
"study-abstract": "Periodontitis is an infectious and inflammatory disease of polymicrobial etiology that can lead to the destruction of bones and tissues that support the teeth. The management of chronic periodontitis (CP) relies heavily on elimination or at least control of known pathogenic consortia associated with the disease. Until now, microbial plaque obtained from the subgingival (SubG) sites has been the primary focus for bacterial community analysis using deep-sequencing. In addition to the use of SubG plaque, here we investigated whether plaque obtained from supragingival (SupG) and tongue dorsum sites can serve as alternatives for monitoring CP-associated bacterial biomarkers. Using SubG, SupG, and tongue plaque DNA from 11 healthy and 13 diseased subjects, we sequenced V3 regions (~200 bases) of the 16S rRNA gene using Illumina sequencing. For the first time, this study demonstrates that SupG and tongue dorsum plaque can serve as alternative sources for detecting and enumerating known and novel bacterial biomarkers of CP. This finding is clinically important because, in contrast with SubG sampling that requires trained professionals, obtaining plaque from SupG and tongue sites is convenient, minimally-invasive, and offers a novel means to track CP-biomarker organisms during treatment outcome monitoring.",
"study-name": "Community structure analysis in chronic periodontitis and novel oral sampling sites for detecting disease indicators",
"data-origination": "SUBMITTED"
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