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"id": "MGYS00005125",
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"bioproject": "PRJEB34744",
"samples-count": 15,
"is-private": false,
"last-update": "2019-10-31T10:49:31",
"secondary-accession": "ERP117698",
"centre-name": "The University of the West Indies, CAve Hill Campus",
"public-release-date": null,
"study-abstract": "Non-Lactobacillus dominant cervicovaginal microbiomes have been associated with vaginal and auto-immune diseases such as bacterial vaginosis and systemic lupus erythematosus (SLE). Using a deep sequencing approach, the microbial composition and structure of the cervicovaginal metagenomes of a group of Afro-Caribbean women (with and without SLE) asymptomatic for vaginal disease were analysed. Community state type (CST) IV predominated the metagenomes of the Afro-Caribbean women. In the healthy group Gardnerella (16.37%) and Prevotella (11.3%) species were more abundant than Lactobacillus (5.06%). Whereas, in women with SLE the most abundant species was Prevotella (17.66%) followed by Lactobacillus (13.60%) and Gardnerella (5.73%). These findings suggest that vaginal health is not strictly dependent on the relative abundance of Lactobacillus species. Additionally, some low abundant pathobionts were 5 to 23 times more common in the SLE cohort. This study offers a new postulate into sex and ethnic differences in the prevalence of SLE.",
"study-name": "Metagenomic analysis of the cervicovaginal microbiome in women with systemic lupus erythematosus: A new insight into sex and ethnic differences",
"data-origination": "SUBMITTED"
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