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"id": "MGYS00002608",
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"bioproject": "PRJEB27867",
"samples-count": 100,
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"last-update": "2018-07-25T09:13:11",
"secondary-accession": "ERP110004",
"centre-name": "Nord University",
"public-release-date": null,
"study-abstract": "Probiotics are live microbial strains incorporated as dietary supplements in feeds and are known to provide health benefits to the host. These live microbes manipulate the gut microbes by suppressing the growth and competing with other intestinal microbes. Lactic acid bacteria (LAB) are potential probiotics that have been widely studied; in this study, we have elucidated the effects of two LAB types (LAB1 & LAB2) isolated from the intestinal content of farmed healthy juveniles of rainbow trout on the distal intestinal microbial communities of Atlantic salmon (Salmo salar). We employed high-throughput 16S rRNA gene amplicon sequencing technique to investigate the intestinal bacterial communities harbouring in the distal intestinal content and mucus of the 3 groups of Atlantic salmon fed diets-devoid of or diets-containing LABs. Our results show that LAB shifts the intestinal microbial profile; LAB supplementation did not show any significant alterations in the alpha diversity of the three groups. However, LAB2 feeding increased the bacterial diversity in the distal intestinal mucus of the fish. Beta diversity analysis showed a significant difference between control and LAB-fed groups. We found intestinal Lactobacillus abundant and dominant in the LAB-fed fish. In addition, few members of the phyla Tenericutes, Actinobacteria, and Spirochaetes were also found to be abundant in the LAB-fed groups. Furthermore, the bacterial association network analysis showed that in the LAB1-fed group significantly abundant and relevant OTUs are closely linked suggesting that they may be highly interactive. We did not find any evidence on cooperation-related runaway effect. These results indicate that dietary probiotics modulate the distal intestinal microbiota of Atlantic salmon. These results are intended to improve the understanding of the modulations and interactions of gut microbiota under the influence of selected probiotic species.",
"study-name": "Lactobacillus dominate in the intestine of Atlantic salmon fed dietary probiotics.",
"data-origination": "SUBMITTED"
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