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"bioproject": "PRJEB27188",
"accession": "MGYS00002413",
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"last-update": "2018-06-13T09:22:29",
"secondary-accession": "ERP109242",
"centre-name": "Nord University",
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"study-abstract": "Prebiotics are food/feed additives intended to sculpt gut microbial communities as they are selectively utilized by the microorganisms to exert beneficial health effects on hosts. Macroalga-derived oligosaccharides are potential prebiotics, and herein, we determined the effects of Laminaria sp.-derived alginate oligosaccharide (AlgOS) on the distal intestinal microbiota of Atlantic salmon (Salmo salar). Using a high-throughput 16S rRNA gene amplicon sequencing technique, we investigated the microbiota harboured in the intestinal content and mucus of Atlantic salmon offered feeds supplemented with 0.5 and 2.5% AlgOS. We found that AlgOS shifts the intestinal microbiota profile; alpha diversity was significantly reduced with 2.5% AlgOS while with 0.5% AlgOS the alteration occurred without impacting the bacterial diversity. Beta diversity showed a significant difference between control and AlgOS-fed groups. AlgOS supplementation facilitated the dominance of Proteobacteria and Spirochaetes, promoting the growth of presumed butyrate producers in the intestine. In addition, 0.5% AlgOS stimulated certain bacteria belonging to Proteobacteria, Spirochaetes and Actinobacteria. This indicates that the low inclusion of AlgOS can plausibly induce a prebiotic effect on the distal intestinal microbiota of Atlantic salmon. These results are expected to generate further interest in the potential of macroalgae-derived oligosaccharides as prebiotics for food and feed applications. ",
"study-name": "Alginate oligosaccharide-induced shift in the intestinal microbiota of salmon.",
"data-origination": "SUBMITTED"
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