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"last-update": "2019-02-28T11:32:15",
"secondary-accession": "ERP107264",
"centre-name": "UNIVERSITY OF BRITISH COLUMBIA",
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"study-abstract": "Hymenolepis diminuta infection in rats is an attractive model for a therapeutic helminthbecause the long-term and stable infection resembles the long-term associations humanshistorically had with helminths and offers the possibility of long-term treatment. Here weinvestigate the ability of H. diminuta to protect rats against colitis induced through applicationof the haptenizing agent DNBS directly to the colon. We test the ability of immature H.diminuta to ameliorate the effects of colitis during the prepatent period, when H. diminutainduces a type 2 immune response. We also test mature H. diminuta (patent period) againstboth moderate (single DNBS application) and severe (two DNBS applications) colitis, a modeldeveloped in this study to assess the effects of H. diminuta on longer-term disease. We monitorthe gut bacterial microbiota over time, as well as measures of rat health and TNFα expression.We show that mature H. diminuta results in lower inflammation, faster recovery and lesserpathology from severe colitis, but has little impact on moderate colitis. Immature H. diminutainduce elevated IL-10 expression, but do not protect against severe colitis. The gut microbiotais disrupted during colitis and does not appear to play an overt role in H. diminuta mediatedprotection.",
"study-name": "The commensal helminth Hymenolepis diminuta ameliorates chemically induced colitis in a rat model system",
"data-origination": "SUBMITTED"
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