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"id": "MGYS00002138",
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"bioproject": "PRJEB24421",
"samples-count": 86,
"accession": "MGYS00002138",
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"last-update": "2018-01-18T14:24:21",
"secondary-accession": "ERP106248",
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"study-abstract": "Background & Aims: Irritable bowel syndrome (IBS) is unlinked to a pathophysiology, but lowering stress (e.g. by yoga) or a low-carbohydrate diet (i.e. low-FODMAP diet, LFD) relief symptoms. The effects of yoga or LFD intervention on the gut microbiota in patients with irritable bowel syndrome was examined for correlations between both treatment options.Methods: Fifty-nine patients with IBS undertook a single-blind, randomized controlled trial involving a yoga or LFD intervention. Bacterial abundance was analyzed by 16S rRNA gene amplicon sequencing at baseline and after 12 weeks using operational taxonomic units (OTUs). Results: LFD resulted in reduction of the overall relative abundance of Firmicutes, especially of the genus Blautia. This was matched by an increase in the relative abundance of bacteria belonging to the phylum Bacteroidetes. This observation appears also as a weak, but not statistically significant trend in the yoga group. Few OTUs showed a similar response to yoga and LFD. The most pronounced was a decrease observed in the family Lachnospiraceae, namely Eubacterium hallii, Blautia wexlerae and Fusicatenibacter saccharivorans.Conclusions: This study suggests that both, yoga and LFD can change the microbiota for some OTUs in a similar way. The reduction in the abundance of Firmicutes in LFD might unfold its effects through a direct change in the gut bacteria composition. In constrast, yoga might indirectly act on the microbiome through the parasympathetic nervous system, which paralleled the effects of LFD for some Lachnospiraceae species. The underlying mechanism of both interventions are open for future research.",
"study-name": "Effect of Yoga and low-FODMAP diet in the intestinal microbiota of patients with IBS",
"data-origination": "SUBMITTED"
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