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"id": "MGYS00006008",
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"accession": "MGYS00006008",
"bioproject": "PRJEB51828",
"is-private": false,
"last-update": "2022-04-11T09:21:25",
"secondary-accession": "ERP136476",
"centre-name": "EMG",
"public-release-date": null,
"study-abstract": "The Third Party Annotation (TPA) assembly was derived from the primary whole genome shotgun (WGS) data set PRJEB3227, and was assembled with SPAdes v3.14.1. This project includes samples from the following biomes: root:Host-associated:Human:Digestive system:Large intestine:Fecal.",
"study-name": "EMG produced TPA metagenomics assembly of PRJEB3227 data set (Follow-up of faecal microbiota in IBS patients).",
"data-origination": "SUBMITTED"
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"type": "biomes",
"id": "root:Host-associated:Human:Digestive system:Large intestine:Fecal",
"links": {
"self": "https://www.ebi.ac.uk/metagenomics/api/v1/biomes/root:Host-associated:Human:Digestive%20system:Large%20intestine:Fecal?format=api"
}
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{
"type": "studies",
"id": "MGYS00000308",
"attributes": {
"samples-count": 32,
"accession": "MGYS00000308",
"bioproject": "PRJEB3227",
"is-private": false,
"last-update": "2016-01-20T14:12:06",
"secondary-accession": "ERP001739",
"centre-name": "CSISP",
"public-release-date": null,
"study-abstract": "Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder in western countries. The definition and treatment of IBS is challenging due to its largely unknown aetiology and the variety of symptoms it can present. Previous studies on IBS suggest subtle alterations in the composition of intestinal microbiota. However, no consensus has been reached regarding the association between specific bacteria and IBS. To overcome the confusion introduced by inter-subject variability and heterogeneity within IBS that is problematic in cross-sectional studies, we undertook a longitudinal study that allowed us to compare samples from single patients at moments with different type and/or severity of symptoms. We present results for two IBS patients with diarrhoea subtype and the healthy relative of one of them. Faecal samples collected every two days the first week and then weekly over two months were analysed through metagenomic and metatranscriptomic approaches. Overall, we detect a greater instability of faecal microbiota in IBS patients when compared to the control, and even larger instability\n associated with acute diarrheoa.\n Bacterial composition and encoded functions were fairly stable throughout. On the contrary, the fraction of active bacteria varied markedly in time. Strong and quick compositional shifts were associated with relapse, although with low reproducibility between and within patients. Similarly, changes in the global pattern of gene expression characterized days of worsening, but we could not identify genes or functions associated with relapse. Our results confirm that the association of microbiota with IBS is rather weak.",
"study-name": "Follow-up of faecal microbiota in IBS patients",
"data-origination": "SUBMITTED"
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"data": [
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"type": "biomes",
"id": "root:Host-associated:Human:Digestive system:Large intestine:Fecal",
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