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"id": "MGYS00002357",
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"accession": "MGYS00002357",
"bioproject": "PRJEB2961",
"samples-count": 278,
"is-private": false,
"last-update": "2018-04-26T09:29:11",
"secondary-accession": "ERP001346",
"centre-name": "CCME-COLORADO",
"public-release-date": null,
"study-abstract": "Variation in the human oral microbial community composition in health and disease has been observed, but factors associated with this variation remain largely unstudied. We characterized inter- and intra-individual variation of microbial communities in the largest cohort to date (264 saliva samples), using culture-independent 16S rRNA pyrosequencing. We followed the temporal dynamics of their salivary microbiota over 10 years spanning adolescence, and determined the influence of human genotype, gender, age, puberty, and weight class on the microbial communities. Participants included 107 healthy individuals sampled mainly at ages 12-13, 17-18 and 22-24, with a few sampled as early as 8 years of age. In contrast to gut or skin microbiomes, there is a core genus-level salivary microbiome; individuals are more similar to themselves and their co-twins in the 12-17 and in the 17-22 cohorts than to the whole sample population, but not over the 10 years from 12 to 22; and human genotype has no significant role in the oral bacterial composition. The data are most consistent with shared environment serving as the main determinant of microbial populations. Twins resemble each other more closely than the whole population at all time-points, but become less similar to each other when they age and no longer cohabit. Several organisms have age-specific abundance profiles, including members of the genera Veillonella, Actinomyces, and Streptococcus. There is no clear effect of weight class, puberty, and gender. The results of this work will provide a basis to further study oral microbes and human health.",
"study-name": "Nurture trumps nature in a longitudinal survey of salivary bacterial communities in twins from early adolescence to early adulthood",
"data-origination": "SUBMITTED"
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