Sample Studies Relationship List

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        {
            "type": "studies",
            "id": "MGYS00005142",
            "attributes": {
                "samples-count": 4357,
                "bioproject": "PRJEB11697",
                "accession": "MGYS00005142",
                "is-private": false,
                "last-update": "2019-12-07T07:43:23",
                "secondary-accession": "ERP013105",
                "centre-name": "WASHINGTON UNIVERSITY CENTER FOR GENOME SCIENCES",
                "public-release-date": null,
                "study-abstract": "Abstract: Immunoglobulin A (IgA) is the major class of antibody secreted by the gut mucosa, where it contributes to barrier function by preventing microbial and food antigens from interacting with host tissues1,2. The lack of metrics for quantifying development of the gut microbiota and mucosal immune system has hindered the ability to dissect the effects of microbial, host and environmental factors on their co-development. Therefore, we subjected fecal samples, collected monthly during the first 3 postnatal years from 40 healthy USA twin pairs, to bacterial 16S rRNA gene sequencing and to fluorescence-activated cell sorting to distinguish IgA-targeted from non-targeted taxa. Applying a machine-learning algorithm (Random Forests), we identified a set of 25 age-discriminatory bacterial taxa whose patterns of representation define a program of microbiota assembly/maturation shared across twin pairs. Remarkably, IgA responses to 30 taxa, including a subset of the age-discriminatory organisms, converge on a pattern shared across twin pairs by the second postnatal year; the observed targeting patterns were not simple reflections of relative abundance or taxonomy. Zygosity, delivery mode, and breast versus formula feeding had small albeit statistically significant effects on targeting. In follow-up studies, young germ-free mice were colonized with fecal microbiota obtained from two twin pairs at 6 and 18 months of age, and fed a sequence of human diets designed to simulate the transition from milk feeding to complementary foods. Distinct age-associated differences in mucosal IgA responses to the transplanted human microbiota were recapitulated in both diet contexts for both twin pairs, suggesting that intrinsic properties of their community members play a dominant role in dictating IgA responses.  This approach can be used to define gut mucosal immune development in health and disease states, and help identify ways to repair or prevent perturbations in this facet of host immunity.",
                "study-name": "Characterizing postnatal co-development of the gut microbiota and mucosal IgA responses in healthy twin pairs and a gnotobiotic mouse model",
                "data-origination": "SUBMITTED"
            },
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                            "id": "root:Host-associated:Human:Digestive system:Large intestine:Fecal",
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