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{
"metadata": {
"accession": "Q9PUT6",
"id": "PTEN_XENLA",
"source_organism": {
"taxId": "8355",
"scientificName": "Xenopus laevis",
"fullName": "Xenopus laevis (African clawed frog)"
},
"name": "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN",
"description": [
"Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3. Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate"
],
"length": 402,
"sequence": "MTAIIKEFVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTNKFSCRVAQYPFEDHNPPQLELIKPFCEDLDQLLSENENVAAIHCKAGKGRTGVMICAYLLHRGKFPRAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNSLEYRPVPLLFHKIEFETIPMFSGSTCNPQFVVYQLKVKIFTSTAGPKRAEKLMYFDFPQPLPVCGDIKVEFFHKQNKVMKKEKMFHFWVNTFFIPGPEEYSEKVENGTLVGEQELDGIYSTERSDNDKEYLTLALTKNDLDKANKDKANRLFSPNFKVKLFFTKTVEESSNSEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQITQITKV",
"proteome": "UP000186698",
"gene": "pten",
"go_terms": [
{
"identifier": "GO:0016791",
"name": "phosphatase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0016311",
"name": "dephosphorylation",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0016314",
"name": "phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0051717",
"name": "inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0051800",
"name": "phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0008285",
"name": "negative regulation of cell population proliferation",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0046856",
"name": "phosphatidylinositol dephosphorylation",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"protein_evidence": 2,
"source_database": "reviewed",
"is_fragment": false,
"in_alphafold": true,
"in_bfvd": false,
"ida_accession": "6c0458621e8ae2ef30ee0993d4f8b118aa51d371",
"counters": {
"domain_architectures": 2806,
"entries": 25,
"isoforms": 0,
"proteomes": 1,
"sets": 3,
"structures": 0,
"taxa": 1,
"dbEntries": {
"cathgene3d": 2,
"profile": 3,
"ssf": 2,
"smart": 2,
"cdd": 1,
"pfam": 2,
"panther": 1,
"pirsf": 1,
"prosite": 1,
"interpro": 10
},
"proteome": 1,
"taxonomy": 1,
"similar_proteins": 2806
}
}
}
