{"metadata":{"accession":"Q9PUT6","id":"PTEN_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN","description":["Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3. Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate"],"length":402,"sequence":"MTAIIKEFVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTNKFSCRVAQYPFEDHNPPQLELIKPFCEDLDQLLSENENVAAIHCKAGKGRTGVMICAYLLHRGKFPRAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNSLEYRPVPLLFHKIEFETIPMFSGSTCNPQFVVYQLKVKIFTSTAGPKRAEKLMYFDFPQPLPVCGDIKVEFFHKQNKVMKKEKMFHFWVNTFFIPGPEEYSEKVENGTLVGEQELDGIYSTERSDNDKEYLTLALTKNDLDKANKDKANRLFSPNFKVKLFFTKTVEESSNSEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQITQITKV","proteome":"UP000186698","gene":"pten","go_terms":[{"identifier":"GO:0016791","name":"phosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016311","name":"dephosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016314","name":"phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051717","name":"inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051800","name":"phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008285","name":"negative regulation of cell population proliferation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0046856","name":"phosphatidylinositol dephosphorylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":2,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"6c0458621e8ae2ef30ee0993d4f8b118aa51d371","counters":{"domain_architectures":2806,"entries":25,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"profile":3,"ssf":2,"smart":2,"cdd":1,"pfam":2,"panther":1,"pirsf":1,"prosite":1,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":2806}}}