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{
    "metadata": {
        "accession": "Q6GNW3",
        "id": "Q6GNW3_XENLA",
        "source_organism": {
            "taxId": "8355",
            "scientificName": "Xenopus laevis",
            "fullName": "Xenopus laevis (African clawed frog)"
        },
        "name": "Kelch-like protein 25",
        "description": [
            "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated eif4ebp1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis"
        ],
        "length": 588,
        "sequence": "MSVSNHENRKSRSSTGSMNIHLFHKPGHADSLLTQLNLLRKRNLFTDIVLLAGNRSFPCHKAVLASSSRYFEAMFSVGLKESQDREVNFQDALHPEVLELLLDYAYSARIILNEENAESLLEAGDMLQFHDIRDAAAEFLEKNLHPANCLNMMLISDAHCCERLLELSWRMCLSNFVELSNTEDFFRLPKLKLMELVLSEELEVEDESLVYEAVMGWIKFDLSIRLDDLPDLLRYVRLALLPDQYLRCLATDELVVRNKLAKEIVEEAARCRTKILQNDGVVTGFCARPRKVNQALLLLGGQTFMCDKIYVMDQKTTEIIPKTDIPSPRKECSACAIGCKVYVTGGKGAENGASKDVWVYDTLHDEWSKAGAMIVARFGHGSAELDNCLYVVGGHTAMAGSFPASPSVSLKQVEHYDPQTDKWSLVAPLREGVSNAAVVGAKLKLFVFGGTSVNREKLPKVQCFDPLQNRWTVAATCPQPWRYTGAALLGNDVIVVGGDTEFSASSAYRFNSETYQWCRFGDVSSKRISCRAVASGNRLYVVGGYCGAQRCKTLDCYDPSTDTWSSVTTVPYSLIPTAFVSTWKYLTA",
        "proteome": "UP000186698",
        "gene": "enc1.2.S",
        "go_terms": [
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 2,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "8adbf343adcc99198b14fede0a76ad771c3d6104",
        "counters": {
            "domain_architectures": 2570,
            "entries": 22,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 3,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 3,
                "ssf": 2,
                "pfam": 4,
                "profile": 1,
                "smart": 3,
                "cdd": 1,
                "pirsf": 1,
                "panther": 1,
                "interpro": 6
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 2570
        }
    }
}