{"metadata":{"accession":"Q6GNW3","id":"Q6GNW3_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"Kelch-like protein 25","description":["Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated eif4ebp1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis"],"length":588,"sequence":"MSVSNHENRKSRSSTGSMNIHLFHKPGHADSLLTQLNLLRKRNLFTDIVLLAGNRSFPCHKAVLASSSRYFEAMFSVGLKESQDREVNFQDALHPEVLELLLDYAYSARIILNEENAESLLEAGDMLQFHDIRDAAAEFLEKNLHPANCLNMMLISDAHCCERLLELSWRMCLSNFVELSNTEDFFRLPKLKLMELVLSEELEVEDESLVYEAVMGWIKFDLSIRLDDLPDLLRYVRLALLPDQYLRCLATDELVVRNKLAKEIVEEAARCRTKILQNDGVVTGFCARPRKVNQALLLLGGQTFMCDKIYVMDQKTTEIIPKTDIPSPRKECSACAIGCKVYVTGGKGAENGASKDVWVYDTLHDEWSKAGAMIVARFGHGSAELDNCLYVVGGHTAMAGSFPASPSVSLKQVEHYDPQTDKWSLVAPLREGVSNAAVVGAKLKLFVFGGTSVNREKLPKVQCFDPLQNRWTVAATCPQPWRYTGAALLGNDVIVVGGDTEFSASSAYRFNSETYQWCRFGDVSSKRISCRAVASGNRLYVVGGYCGAQRCKTLDCYDPSTDTWSSVTTVPYSLIPTAFVSTWKYLTA","proteome":"UP000186698","gene":"enc1.2.S","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"8adbf343adcc99198b14fede0a76ad771c3d6104","counters":{"domain_architectures":2570,"entries":22,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":2,"pfam":4,"profile":1,"smart":3,"cdd":1,"pirsf":1,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":2570}}}