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{
    "metadata": {
        "accession": "Q60XN1",
        "id": "ATX3_CAEBR",
        "source_organism": {
            "taxId": "6238",
            "scientificName": "Caenorhabditis briggsae",
            "fullName": "Caenorhabditis briggsae"
        },
        "name": "Ataxin-3 homolog",
        "description": [
            "Acts as a chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription"
        ],
        "length": 319,
        "sequence": "MSPSDDPISSIFFERQQAALCAQHALNMLLQDSLFTYENLRDLARQMDQMEHDILGNNANAVGRSENMNDSGFFSIQVIEKALETFDLKLINMENPAMAEFKANPLTARAYVLNLREHWFVLRKFGNQWFELNSVKNGPKLLTDTYVKEYLHQFAAENYSIFVVQGILPNSEADDFITLCPVVPKPTDFDKKEPNLVQKFFNSVGRRLGGSQEIPDSQEDRDLAIAMALSMESKESSESSGSDEDQLAKAIEMSLSQDPNIPSTSAAPSELTETPILGPSTSSETPSGRIPSAEQQRRDRAKFLEKLEEEKKSQNVPEE",
        "proteome": "UP000008549",
        "gene": "atx-3",
        "go_terms": [
            {
                "identifier": "GO:0004843",
                "name": "cysteine-type deubiquitinase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016579",
                "name": "protein deubiquitination",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "reviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "41ca483bd3978efeed290a38d72b7e2ed37e7f00",
        "counters": {
            "domain_architectures": 385,
            "entries": 13,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "profile": 2,
                "smart": 2,
                "cathgene3d": 2,
                "pfam": 2,
                "panther": 1,
                "prints": 1,
                "interpro": 3
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 385
        }
    }
}