{"metadata":{"accession":"Q60XN1","id":"ATX3_CAEBR","source_organism":{"taxId":"6238","scientificName":"Caenorhabditis briggsae","fullName":"Caenorhabditis briggsae"},"name":"Ataxin-3 homolog","description":["Acts as a chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription"],"length":319,"sequence":"MSPSDDPISSIFFERQQAALCAQHALNMLLQDSLFTYENLRDLARQMDQMEHDILGNNANAVGRSENMNDSGFFSIQVIEKALETFDLKLINMENPAMAEFKANPLTARAYVLNLREHWFVLRKFGNQWFELNSVKNGPKLLTDTYVKEYLHQFAAENYSIFVVQGILPNSEADDFITLCPVVPKPTDFDKKEPNLVQKFFNSVGRRLGGSQEIPDSQEDRDLAIAMALSMESKESSESSGSDEDQLAKAIEMSLSQDPNIPSTSAAPSELTETPILGPSTSSETPSGRIPSAEQQRRDRAKFLEKLEEEKKSQNVPEE","proteome":"UP000008549","gene":"atx-3","go_terms":[{"identifier":"GO:0004843","name":"cysteine-type deubiquitinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016579","name":"protein deubiquitination","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"41ca483bd3978efeed290a38d72b7e2ed37e7f00","counters":{"domain_architectures":385,"entries":13,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"profile":2,"smart":2,"cathgene3d":2,"pfam":2,"panther":1,"prints":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":385}}}