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{
    "metadata": {
        "accession": "Q5NKV9",
        "id": "ICAM1_GORGO",
        "source_organism": {
            "taxId": "9595",
            "scientificName": "Gorilla gorilla gorilla",
            "fullName": "Gorilla gorilla gorilla (Western lowland gorilla)"
        },
        "name": "Intercellular adhesion molecule 1",
        "description": [
            "Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1"
        ],
        "length": 532,
        "sequence": "MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPPKVILPRGGSVLVTCSTSCDQPTLLGIETPLPKKELLLLGNNQKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKDLTLRCQVEGGAPRANLIVVLLRGEEELKREPAVGEPAEVTTTVPVEKDHHGANFLCRTELDLRPQGLKLFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQWLTCAVILGTQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPPGPRTQFLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPVGESVTVTRDLEGTYLCRARSTQGEVTREVTVNVLSPRYEFVIIAVVAAAVIMGTAGLSTYLYNRQRKIRKYRLQQAQKGTPMKPNTQATPP",
        "proteome": "UP000001519",
        "gene": "ICAM1",
        "go_terms": [
            {
                "identifier": "GO:0005178",
                "name": "integrin binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0007155",
                "name": "cell adhesion",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0098609",
                "name": "cell-cell adhesion",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 2,
        "source_database": "reviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "176d6d905b5d01023d24484f892bed30f7432200",
        "counters": {
            "domain_architectures": 94,
            "entries": 17,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "pfam": 3,
                "ssf": 1,
                "cathgene3d": 1,
                "smart": 1,
                "panther": 1,
                "prints": 2,
                "interpro": 8
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 94
        }
    }
}