{"metadata":{"accession":"Q5NKV9","id":"ICAM1_GORGO","source_organism":{"taxId":"9595","scientificName":"Gorilla gorilla gorilla","fullName":"Gorilla gorilla gorilla (Western lowland gorilla)"},"name":"Intercellular adhesion molecule 1","description":["Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1"],"length":532,"sequence":"MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPPKVILPRGGSVLVTCSTSCDQPTLLGIETPLPKKELLLLGNNQKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKDLTLRCQVEGGAPRANLIVVLLRGEEELKREPAVGEPAEVTTTVPVEKDHHGANFLCRTELDLRPQGLKLFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQWLTCAVILGTQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPPGPRTQFLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPVGESVTVTRDLEGTYLCRARSTQGEVTREVTVNVLSPRYEFVIIAVVAAAVIMGTAGLSTYLYNRQRKIRKYRLQQAQKGTPMKPNTQATPP","proteome":"UP000001519","gene":"ICAM1","go_terms":[{"identifier":"GO:0005178","name":"integrin binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007155","name":"cell adhesion","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0098609","name":"cell-cell adhesion","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":2,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"176d6d905b5d01023d24484f892bed30f7432200","counters":{"domain_architectures":94,"entries":17,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"pfam":3,"ssf":1,"cathgene3d":1,"smart":1,"panther":1,"prints":2,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":94}}}