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{
    "metadata": {
        "accession": "Q4WE63",
        "id": "HSFA_ASPFU",
        "source_organism": {
            "taxId": "330879",
            "scientificName": "Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)",
            "fullName": "Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)"
        },
        "name": "Heat shock transcription factor hsfA",
        "description": [
            "Transcription factor that acts as a negative regulator of gliotoxin production (PubMed:39964163). HsfA is a positive regulator of transcription factor rogA that in turn represses the expression of the gliotoxin cluster-specific transcription factor gliZ (PubMed:39964163). HsfA-positive regulation of rogA expression partially explains hsfA impact on gliotoxin production, although hsfA appears to also negatively regulate gliotoxin synthesis in a rogA/gliZ independent manner (PubMed:39964163). HsfA also positively regulates the expression of gliT and the hsfA/gliT connection acts as a mediator of self-protection against exogenous gliotoxin as gliT is considered a direct self-protection protein by neutralizing the toxicity of gliotoxin (PubMed:39964163)"
        ],
        "length": 799,
        "sequence": "MSSQGVTRKRPAPGTTPTVHPQLSPISNYPAANPGSQLSNDQFLQWGQNPPNVITPPYTDAGSYNVAPYTTNQDVPGATVTASTQLARRQLPNQLVNRGRGYEQTPSVYSDHSGGAGEPGGWGESLDELYRRALVAKREAQAKRKQIPPFVQKLSSFLDESKNTDLIRWSDDGNSFIVLDEDEFAKTLIPELFKHNNYASFVRQLNMYGFHKKVGLSDNSMRASERKNKSPSEYANPYFKRGHPDLLWLIQKPKNTAGQGSKSGKGNVRVKTEEVDENENDDYGEDGASRDDRNRSRQLSLVPGSMMPKDQLAGVYRELQAIRQQQQIISNTINKLRREHEQLYAQAANFQEQHNRHENSINAILTFLATVYNRSLQGQDGPQNLANSFAGVISQDQGNVVDVEDDFPLSALGAANLNSPNAQRSMKKQPLLLKAPPTTDRQNGRATTLSPAGSTYNRSQSRSHSRQPSVTQAGHVEEVFETSPTQKDATNSQNRQYPQSDIMSVIQNTNARNGIPTTFAEFPNVLSSLETSGGNSPLTPNQRADMLRLMANESHTDPNIPVPSDNALITPTPPPMPHNYNGRLASTRAEIDNLMKMQAEQDRSVQNLTNLLQPLSPTGTIPGLAGGENGSVPPPALDLDQIFNNDYFTDIGDLEHNKSNMDLGDTTSSVPAPAPADAPVTTGAEDVKDGSDLFDFDQIPPEGDLFDTSTAAQQQSPSFFNGYDGAGYPGGSGTNGHTLIGHKNPNGDSGRIVETLTDSESTSPSTNVDEVPQYSGPAGLNESHGGKGNGGGAKRRRKA",
        "proteome": "UP000002530",
        "gene": "hsfA",
        "go_terms": [
            {
                "identifier": "GO:0003700",
                "name": "DNA-binding transcription factor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0043565",
                "name": "sequence-specific DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006355",
                "name": "regulation of DNA-templated transcription",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "reviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "92fa2e0a25ba927e7614d2933303af548bde0de6",
        "counters": {
            "domain_architectures": 27852,
            "entries": 9,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "ssf": 1,
                "smart": 1,
                "pfam": 1,
                "panther": 1,
                "prints": 1,
                "interpro": 3
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 27852
        }
    }
}