{"metadata":{"accession":"Q4WE63","id":"HSFA_ASPFU","source_organism":{"taxId":"330879","scientificName":"Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)","fullName":"Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)"},"name":"Heat shock transcription factor hsfA","description":["Transcription factor that acts as a negative regulator of gliotoxin production (PubMed:39964163). HsfA is a positive regulator of transcription factor rogA that in turn represses the expression of the gliotoxin cluster-specific transcription factor gliZ (PubMed:39964163). HsfA-positive regulation of rogA expression partially explains hsfA impact on gliotoxin production, although hsfA appears to also negatively regulate gliotoxin synthesis in a rogA/gliZ independent manner (PubMed:39964163). HsfA also positively regulates the expression of gliT and the hsfA/gliT connection acts as a mediator of self-protection against exogenous gliotoxin as gliT is considered a direct self-protection protein by neutralizing the toxicity of gliotoxin (PubMed:39964163)"],"length":799,"sequence":"MSSQGVTRKRPAPGTTPTVHPQLSPISNYPAANPGSQLSNDQFLQWGQNPPNVITPPYTDAGSYNVAPYTTNQDVPGATVTASTQLARRQLPNQLVNRGRGYEQTPSVYSDHSGGAGEPGGWGESLDELYRRALVAKREAQAKRKQIPPFVQKLSSFLDESKNTDLIRWSDDGNSFIVLDEDEFAKTLIPELFKHNNYASFVRQLNMYGFHKKVGLSDNSMRASERKNKSPSEYANPYFKRGHPDLLWLIQKPKNTAGQGSKSGKGNVRVKTEEVDENENDDYGEDGASRDDRNRSRQLSLVPGSMMPKDQLAGVYRELQAIRQQQQIISNTINKLRREHEQLYAQAANFQEQHNRHENSINAILTFLATVYNRSLQGQDGPQNLANSFAGVISQDQGNVVDVEDDFPLSALGAANLNSPNAQRSMKKQPLLLKAPPTTDRQNGRATTLSPAGSTYNRSQSRSHSRQPSVTQAGHVEEVFETSPTQKDATNSQNRQYPQSDIMSVIQNTNARNGIPTTFAEFPNVLSSLETSGGNSPLTPNQRADMLRLMANESHTDPNIPVPSDNALITPTPPPMPHNYNGRLASTRAEIDNLMKMQAEQDRSVQNLTNLLQPLSPTGTIPGLAGGENGSVPPPALDLDQIFNNDYFTDIGDLEHNKSNMDLGDTTSSVPAPAPADAPVTTGAEDVKDGSDLFDFDQIPPEGDLFDTSTAAQQQSPSFFNGYDGAGYPGGSGTNGHTLIGHKNPNGDSGRIVETLTDSESTSPSTNVDEVPQYSGPAGLNESHGGKGNGGGAKRRRKA","proteome":"UP000002530","gene":"hsfA","go_terms":[{"identifier":"GO:0003700","name":"DNA-binding transcription factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0043565","name":"sequence-specific DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"92fa2e0a25ba927e7614d2933303af548bde0de6","counters":{"domain_architectures":27852,"entries":9,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"smart":1,"pfam":1,"panther":1,"prints":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":27852}}}