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{
    "metadata": {
        "accession": "Q1LUT2",
        "id": "Q1LUT2_DANRE",
        "source_organism": {
            "taxId": "7955",
            "scientificName": "Danio rerio",
            "fullName": "Danio rerio (Zebrafish)"
        },
        "name": "DNA topoisomerase 2",
        "description": [
            "Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand"
        ],
        "length": 1618,
        "sequence": "MSNGAAGSGGLTWVTLFDKNNGAKKEEMNGRGDAGKSEVVKKESSKKMSVERIYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFDEEIGMNLREISFVPGLYKIFDEILVNAADNKQRDKNMTTIKITIDPESNTISVWNNGKGIPVVEHKDEKMYVPALIFGHLLTSSNYDDNEKKVTGGRNGYGAKLCNIFSLKFTVETACKEYKRSFKQTWTENMGKSNEAKIKYFDGEDFTCVTFQPDLAKFNMEKLDKDIVALLTRRAYDVAGSCRGVKVILNGKKLPVNSFRSYVDFYVKDKLDETGVALKVVNETVNERWEVCLTMSEKGFQQISFVNSIATTKGGRHIDYIVDQIVGKLIEVVKKKNKAGVSVKPFQVKNHLWVFVNALIENPTFDSQTKENMTLQTKSFGSKCALSEKFIRAATNCGIVESILNWVKFKAQTQLNKKCSSVKHSKIKGIPKLDDANDAGGKHSSECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREATHKQIMENAEINNIIKILGLQYKKSYDDPESLKSLRYGRIMIMTDQDQDGSHIKGLLINFFHHNWPSLLKHTFLEEFITPIVKASKNKQEVSFYSIPEFEEWKKHTESYKTWHIKYYKGLGTSTSKEAKEYFSDMERHRIMFKYNGTEDDAAITLAFSKKKTDDRKEWLTNFMEDRRQRRMHGLPEQYLYGTSTRHLSYNDFINKELILFSNSDNERSIPSLVDGLKPGQRKVLFTCVKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNVNILQPLGQFGTRINGGKDAASPRYIFTMLSPLAKLLFPAVDSSLLKFLYDDNQKVEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDPREIVNNINRMLNHQDPLPMLPSYKNFKGTIHELGQNQYLVSGEVSVLDKNTIEISELPVRTWTQAYKESVLEPMLQGTDKTPPLISDYKEYHTDTTVKFVVRMTEEKLAQAEAAGLHKVFKLQSSLTCNSMVLFDHMGCMKRYESVQEILKEFFELRLHYYKLRKDWLVGSLGAESAKLSNQARFVLEKIEGKLSIENKSKRDLIRMLVQRGYESDPVAAWNKAQEKSLEEEDGGGNDSDSSVDSGSFSGPNFNYILNMPLWCLTKEKVEELLKQRDLKKAELNELQSKTSENLWREDLAVFIEELDRVEEQEKESVNLGKAVKLVKGKVGKPKVKKMQLEETLPSPFGRRVEPQITLAMKADASKKLTKKKKGEIDAAVKLEIDDDSALGSNGGENSLISPSGLPNPGAKPKAPRVKREKKEPGTPRQRKPAGAKGPAKKVKKRNPWSDDDEGGDDDRSDIELDECEPVIPRDSTSRRASAVKAKYTFDFSEEEEEEEDGDEEQENDASASPVHSFKNTEQHDDEVDDDDDIFPPKTTFTLPTSTAKKKNPEPVLPSKTTYDDKISDDDMKSDSDGDRGPVFSSYSSSSAFEKPAKKTAKKPVDTPPKPKKAPVKAKKPDTSVWDSDSDTGTKKPPASKGSGKGRSKKRKQSSLEEDEYSPMKKHGKSATSRKPKKAASDDEDDDDDDETGFNSFSHLDSGRDRSGRAKKEVKYFAESDNDDDDDMFD",
        "proteome": "UP000000437",
        "gene": "top2b",
        "go_terms": [
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0003918",
                "name": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005524",
                "name": "ATP binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006265",
                "name": "DNA topological change",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0006259",
                "name": "DNA metabolic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 1,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "168092c496ae46f2c3e92c2fab72b16f7b9c4e1b",
        "counters": {
            "domain_architectures": 1526,
            "entries": 47,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 7,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 3,
                "cathgene3d": 7,
                "cdd": 4,
                "pfam": 6,
                "smart": 3,
                "profile": 2,
                "panther": 1,
                "prints": 2,
                "prosite": 1,
                "interpro": 18
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 1526
        }
    }
}